{"id":11109,"date":"2021-04-16T20:46:26","date_gmt":"2021-04-16T18:46:26","guid":{"rendered":"https:\/\/www.texia.eu\/?p=11109"},"modified":"2024-06-14T11:18:37","modified_gmt":"2024-06-14T09:18:37","slug":"clinic-trials-an-ace-based-boisson-elder-tree-syrup-enbodies-a-draconian-remedy-to-prevent-and-combat-seasonal-flus-and-covid-symptoms-eng-ita","status":"publish","type":"post","link":"https:\/\/www.texia.eu\/en\/clinic-trials-an-ace-based-boisson-elder-tree-syrup-enbodies-a-draconian-remedy-to-prevent-and-combat-seasonal-flus-and-covid-symptoms-eng-ita\/","title":{"rendered":"[JOSR ENG-ITA-CLINIC TRIALS]- An ACE-based boisson (Elder tree syrup)  enbodies a draconian remedy to prevent and combat seasonal flus and covid symptoms. (ENG-ITA)"},"content":{"rendered":"<p><img loading=\"lazy\" class=\"wp-image-11118 alignnone\" src=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo-300x118.jpg\" alt=\"\" width=\"470\" height=\"185\" srcset=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo-300x118.jpg 300w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo-768x301.jpg 768w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo-16x6.jpg 16w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo-700x275.jpg 700w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/josr-logo.jpg 910w\" sizes=\"(max-width: 470px) 100vw, 470px\" \/><\/p>\n<pre><strong><span dir=\"ltr\">IOSR Journal Of Pharmacy <\/span><span dir=\"ltr\">(e)<\/span><span dir=\"ltr\">-<\/span><span dir=\"ltr\">ISSN: 2250<\/span><span dir=\"ltr\">-<\/span><span dir=\"ltr\">3013, (p)<\/span><span dir=\"ltr\">-<\/span><span dir=\"ltr\">ISSN: 2319<\/span><span dir=\"ltr\">-<\/span><span dir=\"ltr\">4219<\/span><span dir=\"ltr\">Volume 1<\/span><span dir=\"ltr\">1<\/span><span dir=\"ltr\">, Issue <\/span><span dir=\"ltr\">4<\/span><span dir=\"ltr\">Series. <\/span><span dir=\"ltr\">I<\/span><span dir=\"ltr\">(<\/span><span dir=\"ltr\">April<\/span><span dir=\"ltr\">202<\/span><span dir=\"ltr\">1<\/span><span dir=\"ltr\">), PP. <\/span><span dir=\"ltr\">01<\/span><span dir=\"ltr\">-<\/span><span dir=\"ltr\">0<\/span><span dir=\"ltr\">5<\/span><span dir=\"ltr\">www.iosrphr.org<\/span><\/strong><\/pre>\n<h4><span dir=\"ltr\">An ACE<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">based boisson (Elder tree syrup) enbodies a draconian <\/span><span dir=\"ltr\">remedy to prevent and combat seasonal flus and covid symptoms.<\/span><\/h4>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">R&amp;D Texia \u00b9, Lorenzo Martini\u00b2 <\/span><\/strong><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">\u00b9 <\/span><span dir=\"ltr\">Texia Research, Turin,<\/span><span dir=\"ltr\">\u00b2 <\/span><span dir=\"ltr\">Department of Pharmaceutical Biotechnologies University of Siena<\/span><\/strong><\/p>\n<pre><strong><span dir=\"ltr\">Received <\/span><span dir=\"ltr\">22<\/span><span dir=\"ltr\">March 2021; Accepted <\/span><span dir=\"ltr\">7<\/span><span dir=\"ltr\">April<\/span><span dir=\"ltr\">2021<\/span><\/strong><\/pre>\n<p><strong><span dir=\"ltr\">Abstract<\/span><span dir=\"ltr\">: <\/span><\/strong><span dir=\"ltr\">In occasion of the dramatic advent of Coranavirudae and its variants in the World, during the winter <\/span><span dir=\"ltr\">2020<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">2021<\/span><span dir=\"ltr\">, few have been the physicians who have supposed that manifold symptoms were evoked by 4 strains <\/span><span dir=\"ltr\">of seasonal flu from South America or Asia and asserted that the patients were infected by covid.<\/span><span dir=\"ltr\">The AA have focuse their attention on a panel group of 6 youn<\/span><span dir=\"ltr\">g workers who manifested odd symptoms, that <\/span><span dir=\"ltr\">could be caused by flu or by covid (these strangers did not have Healf Insurance Fund in our land).<\/span><span dir=\"ltr\">The AA have tried to cure these volunteers administering them an alder tree soft drink added with three <\/span><span dir=\"ltr\">vitamins<\/span><span dir=\"ltr\">, that correspond to the famous acronym ACE.<\/span><span dir=\"ltr\">Symtoms tend to disappear at all after 6 days of treatment.<\/span><\/p>\n<p><strong><span dir=\"ltr\">Keywords<\/span><\/strong><span dir=\"ltr\">: <\/span><span dir=\"ltr\">A\/Guangdong<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Maonan\/SWL 1536\/2019 [H1N1] pdm09<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like, A\/Hong Kong\/2671\/2019 [H3N2]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like, B\/Washington\/02\/2019 [B\/Victoria lineage]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like), B\/Ph<\/span><span dir=\"ltr\">uket\/3073\/2013 [B\/Yamagata lineage]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like), Elder <\/span><span dir=\"ltr\">tree syrup, Vitamin D<\/span><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">I.<\/span><span dir=\"ltr\">BACKGROUND<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The conventicle of unprovided physicians and last<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">minute \u201ccerusichielli\u201d(this apax is napoli<\/span><span dir=\"ltr\">tean, idest bad <\/span><span dir=\"ltr\">surgeons and asinine doctors) have been not capable, almost in Italy, to clarify the difference beteween some <\/span><span dir=\"ltr\">strain of trivial seasonal flu and real covid.<\/span><span dir=\"ltr\">Rather nobody has thought that during winter 2020<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">21 almost four diverse strains fr<\/span><span dir=\"ltr\">om Asia and America were <\/span><span dir=\"ltr\">in the limelight:<\/span><\/p>\n<p><span dir=\"ltr\">A\/Guangdong<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Maonan\/SWL 1536\/2019 [H1N1] pdm09<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like, <\/span><span dir=\"ltr\">A\/Hong Kong\/2671\/2019 [H3N2]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like, <\/span><\/p>\n<p><span dir=\"ltr\">B\/Washington\/02\/<\/span><span dir=\"ltr\">2019<\/span><\/p>\n<p><span dir=\"ltr\"> [B\/Victoria lineage]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like)<\/span><span dir=\"ltr\">B\/Phuket\/3073\/2013<\/span><\/p>\n<p><span dir=\"ltr\"> [B\/Yamagata lineage]<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">like) <\/span><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0 And all these viruses are ver<\/span><span dir=\"ltr\">y contagious, but few were the wise doctors who had understood that some <\/span><span dir=\"ltr\">symptoms were to be tributed to a trivial flus and not to covid.<\/span><span dir=\"ltr\">The past winter strains of flu were characterized by the following symptoms:<\/span><span dir=\"ltr\">sudden improvement of fever (till 102.2<\/span><span dir=\"ltr\">\u00b0 F)<\/span><span dir=\"ltr\">fatigue and exhaustion, muscle and joint pains,<\/span><span dir=\"ltr\">stuffy and runny nose.<\/span><span dir=\"ltr\">Each of everyone of these cerusics should have prescribed the covid swab to the patient in order to be aware of <\/span><span dir=\"ltr\">the presence of Coronavirus and not of other simplest viruses even b<\/span><span dir=\"ltr\">ecause Covid is accompanied by <\/span><span dir=\"ltr\">unmistak<\/span><span dir=\"ltr\">ably<\/span><span dir=\"ltr\">alert<\/span><span dir=\"ltr\">beacon<\/span><span dir=\"ltr\">as<\/span><span dir=\"ltr\">loss of smell and taste, a the typical smoker\u2019s cough.feeling of bearing river <\/span><span dir=\"ltr\">stones in the lungs, sensation of having sand in the throat, very severe headache, highest fever and difficulty of <\/span><span dir=\"ltr\">t<\/span><span dir=\"ltr\">urning left and right own head with neck pain.<\/span><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 he AA of this report desire to focus their attention to the eventual prevention when symptoms of trivial <\/span><span dir=\"ltr\">flus could grow covid and the same AA face the problems of the rapida passage from a very cold extern<\/span><span dir=\"ltr\">al <\/span><span dir=\"ltr\">atmosprere to a very torrid one and viceversa.<\/span><span dir=\"ltr\">These are the chief causes of developping covid in sane people,especially workers.<\/span><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The AA have recruited 6 youngmen, three of those attend to a furnace where temperature generally <\/span><span dir=\"ltr\">raise to 50<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">60\u00b0C and too <\/span><span dir=\"ltr\">often exit form their work place to smoke sigarettes or cigars \u00e0 l\u2019exterieur, and the <\/span><span dir=\"ltr\">other three are lumberjacks who generally go to work very early in the morning (when atmosperical temperature <\/span><span dir=\"ltr\">goes down below zero) and sometimes crouch near a fire in t<\/span><span dir=\"ltr\">heir huts or shacks in order to heat up their noses <\/span><span dir=\"ltr\">and hands or feet.<\/span><span dir=\"ltr\">All these volunteers manifest the typical symptoms of trivial flu, especially in the night, but sometimes <\/span><span dir=\"ltr\">they show even signs of the advent of covid infection though.<\/span><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The AA propose th<\/span><span dir=\"ltr\">e administration of three vitemins to prevent and cure the occurence of an eventual Covid <\/span><span dir=\"ltr\">infection.<\/span><span dir=\"ltr\">These vitamins constitute the over the world famous boisson ACE.<\/span><span dir=\"ltr\">The same volunteers are suggested to assume even modest dosages of vitamin D (4000 I.U.) <\/span><span dir=\"ltr\">pro\/day.<\/span><span dir=\"ltr\">The assumption of Vit D should be fully optional, as the AA will explain further.<\/span><span dir=\"ltr\">Nowaday Vit D is quite fashionable in covid<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">therapy, both preventive and curative too.<\/span><span dir=\"ltr\">Effectively, recently, <\/span><span dir=\"ltr\">on the other hand, scientific and eminent <\/span><span dir=\"ltr\">evidence sup<\/span><span dir=\"ltr\">porting the role of vitamin D in <\/span><span dir=\"ltr\">several health and disease processes, in particular in acute respiratory tract infection, remains patchy. Data from <\/span><span dir=\"ltr\">observational studies have suggested that vitamin D supplementation\u00a0 <\/span><span dir=\"ltr\">can lower the odds of developing re<\/span><span dir=\"ltr\">spiratory infections, particularly in vitamin D<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">deficient groups, but <\/span><span dir=\"ltr\">randomised trials have yielded mixed results.<\/span><span dir=\"ltr\">(1)<\/span><span dir=\"ltr\">Now, vitamin A (2<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">8) is supposed <\/span><span dir=\"ltr\">to<\/span><span dir=\"ltr\">support <\/span><span dir=\"ltr\">T<\/span><span dir=\"ltr\">lymphocytes, that are involved in the immunological <\/span><span dir=\"ltr\">\u00e9quipment.<\/span><span dir=\"ltr\">In fact <\/span><span dir=\"ltr\">Vitamin<\/span><span dir=\"ltr\">A suppor<\/span><span dir=\"ltr\">ts the differentiation of<\/span><span dir=\"ltr\">T<\/span><span dir=\"ltr\">lymphocites, especially in the spleen.<\/span><span dir=\"ltr\">Vitamin C<\/span><span dir=\"ltr\">(9) <\/span><span dir=\"ltr\">does support<\/span><span dir=\"ltr\">immune function<\/span><span dir=\"ltr\">s and its supplementation<\/span><span dir=\"ltr\">improves chemotaxis, enhances <\/span><span dir=\"ltr\">neutrophil phagoc<\/span><span dir=\"ltr\">ytosis and<\/span><span dir=\"ltr\">lymphocyte proliferation<\/span><span dir=\"ltr\">in thymus, lymph nodes.<\/span><\/p>\n<p><span dir=\"ltr\">They are represented chiefly by:<\/span><\/p>\n<p><span dir=\"ltr\">plasmablasts<\/span><\/p>\n<p><span dir=\"ltr\">plasmacells<\/span><span dir=\"ltr\">lymphocytes T NK<\/span><span dir=\"ltr\">lymphocytes T CD8 <\/span><\/p>\n<p><span dir=\"ltr\">+<\/span><span dir=\"ltr\">lymphocytes CD4 <\/span><\/p>\n<p><span dir=\"ltr\">+<\/span><span dir=\"ltr\">lymphocytes T<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">delta<\/span><\/p>\n<p><span dir=\"ltr\">Vit C besides increaes the proliferation and differe<\/span><span dir=\"ltr\">ntiaton <\/span><span dir=\"ltr\">of inflammatory cytokines<\/span><span dir=\"ltr\">and interleukins.<\/span><span dir=\"ltr\">Finally <\/span><span dir=\"ltr\">Vitamin E (10<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">65<\/span><span dir=\"ltr\">) is a fat<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">soluble antioxidant that can protect the polyunsaturated fatty acids (PUFAs) <\/span><span dir=\"ltr\">in the membrane from oxidation, regulate the production of reactive oxygen species (ROS) an<\/span><span dir=\"ltr\">d reactive nitrogen <\/span><span dir=\"ltr\">species (RNS), and modulate signal transduction. Immunomodulatory effects of vitamin E have been observed <\/span><span dir=\"ltr\">in animal and human models under normal and disease.conditions. With advances in understating of the development, function, and regulation of dendritic cells (DCs), macrophages, natural killer (NK) cells, T cells, and B cells, recent studies have focused on vitamin E\u2019s effects on specific immune cells.<\/span><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">II.<\/span><span dir=\"ltr\">MATERIALS AND METHODS<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The AA recruited 6 men (26, 28, 28,29, 30, 31 and 33 y. old and therefore Case A,B,C,D,E and F)<\/span><span dir=\"ltr\">who showed the very symptoms of typical seasonal flu or covid.<\/span><span dir=\"ltr\">They were strangers and did not have the health insurance fund in our country, anyway odd man<\/span><span dir=\"ltr\">ifestations were <\/span><span dir=\"ltr\">evident.<\/span><span dir=\"ltr\">Hard cough<\/span><span dir=\"ltr\">Cold<\/span><span dir=\"ltr\">Headache<\/span><span dir=\"ltr\">Fever<\/span><span dir=\"ltr\">Pain in turning head and pupils of their own eyes<\/span><span dir=\"ltr\">Skeletal<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">muscular troubles.<\/span><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The AA prayed the volunteers to assume twice a day, before breakfast in the morning and before supper in the <\/span><span dir=\"ltr\">night, a gla<\/span><span dir=\"ltr\">ss of elder tree syrup added with elevated dosages of Vit A,E and C.<\/span><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">III.<\/span><span dir=\"ltr\">RESULTS<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The tretment has lasted 6 days and here follows the Table where it is noticeable how disturbs tend to disappe<\/span><span dir=\"ltr\">ar <\/span><span dir=\"ltr\">day by day.<\/span><\/p>\n<p><img loading=\"lazy\" class=\"wp-image-11110 aligncenter\" src=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-300x109.jpg\" alt=\"\" width=\"499\" height=\"181\" srcset=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-300x109.jpg 300w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-1024x373.jpg 1024w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-768x280.jpg 768w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-16x6.jpg 16w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-700x255.jpg 700w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu.jpg 1309w\" sizes=\"(max-width: 499px) 100vw, 499px\" \/><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">IV.<\/span><span dir=\"ltr\">DISCUSSIONS<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 It is noticeable that there is not at all any correlation among the progressive day of treatment, disappearance of <\/span><span dir=\"ltr\">the disturb and thereby age of the volunteer.<\/span><span dir=\"ltr\">Anyway a<\/span><span dir=\"ltr\">fter 6 days of treatment every disfonctionnement evaneshes.<\/span><\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">REFERENCES<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">[1].<\/span><span dir=\"ltr\">The Lancet Diabets &amp; Endocrinology, 9 (21)<\/span><span dir=\"ltr\">[2].<\/span><span dir=\"ltr\">Anderson K.E. et al., Adv. Clin. Chem., 1976, 18, 247.<\/span><span dir=\"ltr\">[3].<\/span><span dir=\"ltr\">Blomhoff R. et al., S<\/span><span dir=\"ltr\">cience, 1990, 250 (4979), 399.<\/span><span dir=\"ltr\">[4].<\/span><span dir=\"ltr\">Clagett<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Dame M., DeLuca H.F., Annu. Rev. Nutr., 2002, 22, 347.<\/span><span dir=\"ltr\">[5].<\/span><span dir=\"ltr\">D\u2019Ambrosio D.N. et al., Nutrients., 2011, 3 (1), 63.<\/span><span dir=\"ltr\">[6].<\/span><span dir=\"ltr\">Feldman M.H., Schlezinger N.S., Arch. Neurol., 1970, 22 (1), 1.<\/span><span dir=\"ltr\">[7].<\/span><span dir=\"ltr\">Guillonneau M., Jacqz<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Aigrain E., Arch. P<\/span><span dir=\"ltr\">ediatr., 1997, 4 (9), 867.<\/span><span dir=\"ltr\">[8].<\/span><span dir=\"ltr\">Kowalski T.E. et al., Am. J. Med., 1994, 97 (6), 523.<\/span><span dir=\"ltr\">[9].<\/span><span dir=\"ltr\">H.C. Gorton e K Jarvis,<\/span><span dir=\"ltr\">The effectiveness of vitamin C in preventing and relieving the symptoms of <\/span><span dir=\"ltr\">virus<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">induced respiratory infections<\/span><span dir=\"ltr\">, in<\/span><span dir=\"ltr\">Journal of Manipulative and Physiological Therapeutics<\/span><span dir=\"ltr\">, 22(8), <\/span><span dir=\"ltr\">ottobre 1999, pp.<\/span><span dir=\"ltr\">530<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">3.<\/span><span dir=\"ltr\">[10].<\/span><span dir=\"ltr\">Rimbach G et al.: Regulation of cell signallin<\/span><span dir=\"ltr\">g by vitamin E. 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Annu Rev Nutr. 2007; 27:347<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">362.<\/span><span dir=\"ltr\">[19].<\/span><span dir=\"ltr\">Christen S, Woodall AA, Shigenaga MK, Southwell<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Keely PT, Duncan MW, Ames BN. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol traps mu<\/span><span dir=\"ltr\">tagenic electrophiles such as NO(X) and complements alpha<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol: <\/span><span dir=\"ltr\">physiological implications. Proc Natl Acad Sci U S A. 1997; 94(7):3217<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">3222.<\/span><span dir=\"ltr\">[20].<\/span><span dir=\"ltr\">Li D, Saldeen T, Mehta JL. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol decreases ox<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">LDL<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">mediated activation of nuclear factor<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">kappaB and<\/span><span dir=\"ltr\">apoptosis in human coronary artery endothelial cells. Biochem Biophys Res Commun. 1999; <\/span><span dir=\"ltr\">259(1):157<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">161.<\/span><span dir=\"ltr\">[21].<\/span><span dir=\"ltr\">Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, <\/span><span dir=\"ltr\">selenium, and subsequent prostate cancer. J Natl Can<\/span><span dir=\"ltr\">cer Inst. 2000; 92(24):2018<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">2023.<\/span><span dir=\"ltr\">[22].<\/span><span dir=\"ltr\">Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, the major form of vitamin E in the <\/span><span dir=\"ltr\">US diet, deserves more attention. Am J Clin Nutr. 2001; 74(6):714<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">722<\/span><\/p>\n<h4>ITA<\/h4>\n<h3 style=\"text-align: center\">Una bevanda a base di ACE (sciroppo di sambuco nero addizionato) incarna un rimedio draconiano per combattere sia le influenze stagionali che i sintomi del covid.<\/h3>\n<p>&nbsp;<\/p>\n<p><strong>abstract:<\/strong>in occasione dell&#8217;avvento del Coronavirus e delle sue varianti nel mondo intiero, durante l&#8217;inverno 2020-2021 sono stati ben pochi i medici che hanno supposto che molti dei sintomi erano invece evocati da 4 ceppi di influenze stagionali dal Sud America o dall&#8217;Africa, asserendo che i pazienti erano affetti senza dubbio da covid.<\/p>\n<p>Gli AA hanno focalizzato la loro attenzione su 6 operai che presentavano strani sintomi riconducibili a volgare influenze stagionali o covid (purtroppo questi lavoratori stranieri non godono della cassa mutualistica previdenziale qui in Patria).<\/p>\n<p>Gli AA hanno tentato di curare i volontari somministrando loro una bevanda a base di sambuco nero addizionata dalle vitamine A,C e E.<\/p>\n<p>Hanno dimostrato che i sintomi sono scomparsi definitivamente dopo solo sei giorni di trattamento.<\/p>\n<p><strong>Parole chiave<\/strong>: A\/Guangdong-Maonan\/SWL 1536\/2019 [H1N1] pdm09-like, A\/Hong Kong\/2671\/2019 [H3N2]- like, B\/Washington\/02\/2019 [B\/Victoria lineage]-like), B\/Phuket\/3073\/2013 [B\/Yamagata lineage]-like), sciroppo di sambuco, Vitamina D.<\/p>\n<p style=\"text-align: center\"><strong>Introduzione<\/strong><\/p>\n<p>La combriccola di cerusici improvvisati e cerusichielli dell&#8217;ultim&#8217;ora (apax napoletano che significa scarognati medici e dottori asinini) non sono stati affatto capaci di chiarire la differenza fra influenza stagionale e vero e proprio covid in atto.<\/p>\n<p>Nessuno di loro ha pensato per un momento che i sintomi potessero provenire dai ceppi che sono arrivati in Europa dall&#8217;Oriente e dall&#8217;America latina, e cio\u00e8 i seguenti:<\/p>\n<p>A\/Guangdong-Maonan\/SWL 1536\/2019 [H1N1] pdm09-like, A\/Hong Kong\/2671\/2019 [H3N2]-like, B\/Washington\/02\/2019 [B\/Victoria lineage]-like) B\/Phuket\/3073\/2013 [B\/Yamagata lineage]-like).<\/p>\n<p>Ora tutti questi virus sono altamente contagiosi ma solo pochissimi dottori esperti hanno individuato che la causa dei sintomi era da attribuire ai virus influenzali e non al covid vero e proprio.<\/p>\n<p>L&#8217;inverno scorso i ceppi dell&#8217; influenza erano caratterizzati dai seguenti sintomi:<\/p>\n<p>innalzamento improvviso della temperatura corporea (fino a 102\u00b0F)<\/p>\n<p>spossatezza e stanchezza muscolare<\/p>\n<p>dolori alle giunture ossee<\/p>\n<p>naso occluso o rinorrea.<\/p>\n<p>Ciascuno di questi cerusici avrebbero dovuto prescrivere il tampone nasofaringeo per escludere la presenza del Coronavirus\u00a0 e non di altri virus vaganti anche perch\u00e9 il covid \u00e8 sempre accompagnato da segnali di allarme ben riconoscibili, tipo la perdita dell&#8217;olfatto e del gusto, tosse tipica del tabagista,sensazione di sopportare delle pietre di fiume dentro i polmoni o di sabbia nella gola, febbre molto lata e difficolt\u00e0 di voltare la testa a destra e sinistra senza avvertire forte dolore al collo.<\/p>\n<p>Gli AA di questo report desiderano concentrarsi sull&#8217;eventuale prevenzione qualora certi\u00a0 sintomi tipici di volgari influenze\u00a0 \u00a0potessero trasformarsi in covid conclamato e gli stessi AA hanno i problemi del passaggio rapido da un&#8217;atmosfera estremamente fredda al&#8217;esterno a una molto torrida all&#8217;interno degli ambienti di casa o di lavoro e viceversa.<\/p>\n<p>Queste potrebbero essere le vere cause della trasformazione da semplice influenza in covid, specialmente negli operai.<\/p>\n<p>Gli AA hanno scelto 6 giovani operai, tre dei quali lavorano in una fornace dove la temperatura sovente raggiunge i 60 gradi e spesso escono per fumare una sigaretta fuori dello stabilimento al freddo e all&#8217;umidit\u00e0 e<\/p>\n<p>gli altri tre che lavorano come boscaioli che cominciano la mattina presto con temperature atmosferiche sotto le zero e spesso si accovacciano vicino al fuoco nella loro capanna per riscaldarsi naso, mani o piedi.<\/p>\n<p>Tutti costoro manifestano i tipici segni della volgare influenza, specialmente nocte tempore, ma talvolta\u00a0 \u00a0 sembra proprio che manifestino sintomi da covid.<\/p>\n<p>Gli AA propongono di somministrare le tre vitamine al fine di prevenire e\/o curare l&#8217;aggressione dell&#8217;eventuale infezione da covid.Queste vitamine costituiscono la famissima bevanda ACE.Gli stessi volontari sono stati pregati di assumere anche modeste dosi di vitamina D (4000U.I.) al giorno.L&#8217;assunzione di Vit. D deve essere affatto opzionale, come spiegheranno di seguito gli stessi AA.<\/p>\n<p>Oggi\u00a0 la Vitamina D \u00e8 molto in voga nella terapia del covid, sia come curativa che come preventiva.<\/p>\n<p>In effetti, recentemente, d&#8217;altra parte, l&#8217;evidenza scientifica e purtuttavia eminente che suffraga il ruolo della vitamina D in molti processi di malattie, in particolare nelle infezioni\u00a0 acute del tratto respiratorio, rimane confusa e discontinua.Dati ottenuti da studi osservazionali hanno suggerito che la supplementazione di vitamina D pu\u00f2 decrementare le strane infezioni delle vie respiratorie, particolarmente nei gruppi di individui che soffrono di ipovitaminosi D, ma invece esperienze randomizzate hanno condotto a risutati molto interessanti.<\/p>\n<p>Ora, si suppone anche che la Vitamina A supporta la liberazione di linfociti T, che sono coinvolti nel corredo immunologico.Infatti la Vitamina A regola la differenziazione dei linfociti T, specialmente a livello della milza.La Vitamina C invece supporta tutte le funzioni immunitarie in generale e la sua somminiztrazione comporta senz&#8217;altro un incremento della chemiotassi, della fagocitosi neutrofila e della proliferazione linfocitaria a livello del timo, i cosiddetti linfonodi,Questi sono rappresentati per lo pi\u00f9 da:<\/p>\n<p>plasmablasti,<\/p>\n<p>plasmacellule,<\/p>\n<p>linfociti T, NK l<\/p>\n<p>linfociti\u00a0 T CD8 + linfociti CD4 + linfociti T-gamma-delta\u00a0 .<\/p>\n<p>Inoltre la Vit C incrementa la proliferazione e la differenziazione delle citochine infiammatorie e delle interleuchine.Infine, la Vit E \u00e8 un antiossidante per eccellenza, liposolubile che pu\u00f2 proteggere gli acidi grassi nella membrana dall&#8217;ossidazione, \u00e8 capace di regolare la produzione delle specie ossigeno-reattive (ROS) e delle specie Azoto-reattive (RNS) e modulare la transduzione.<\/p>\n<p>Gli effetti immunomodulatori della vit.E sono stati ben documentati in modelli animali e umani in condizioni di normalit\u00e0 e di malattia.<\/p>\n<p>Con l&#8217;avanzare della comprensione dello sviluppo, funzione e regolazione delle cellule dendritiche, dei macrofagi dei Natural Killers e delle cellule B, studi ancor pi\u00f9 recenti hanno puntualizzato gli effetti globali della Vit. E su cellule immunospecifiche.<\/p>\n<p style=\"text-align: center\"><strong>Metodi e Strumenti<\/strong><\/p>\n<p>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Gli AA hanno reclutato 6 uomini (26,28, 28,29,301,31 e 33 anni di et\u00e0, e cio\u00e8 Csi A,B,S,D,E e F) che mostravano sintomi concreti delle volgari influenze stagionali o del covid stesso.Erano tutti di origine straniera e, come gi\u00e0 premesso, non hanno la cassa assenzialistica medica nel nostro paese), e comunque manifestavamo segni evidenti e ben riconoscibili.<\/p>\n<p>Tosse canina, cefalea, febbre, dolori acuti nel voltare la testa e le pulippe dei loro occhi e anche dolori scheletro-muscolari.<\/p>\n<p>Gli AA hanno pregato i volontari di assumere due volte al giorno, prima di colazione la mattina e la sera prima di cena, un bicchiere della bevanda addizionata di elevate percentuali di ACE.<\/p>\n<p style=\"text-align: center\"><strong>Risultati<\/strong><\/p>\n<p style=\"text-align: left\">in tabella I sono riportati per ogni singolo caso i giorni di trattamento e la scomparsa dei vari disturbi dopo i diversi giorni di cura.<\/p>\n<p>Tabella I:<\/p>\n<p><img loading=\"lazy\" class=\"wp-image-11110 aligncenter\" src=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-300x109.jpg\" alt=\"\" width=\"474\" height=\"172\" srcset=\"https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-300x109.jpg 300w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-1024x373.jpg 1024w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-768x280.jpg 768w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-16x6.jpg 16w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu-700x255.jpg 700w, https:\/\/www.texia.eu\/wp-content\/uploads\/2021\/04\/ace-flu.jpg 1309w\" sizes=\"(max-width: 474px) 100vw, 474px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><strong>Discussioni<\/strong><\/p>\n<p>Si pu\u00f2 evidenziare che non sussiste alcuna correlazione tra il gioro progressivo di trattamento. la scomparsa dei vari disturbi e inoltre l&#8217;et\u00e0 del soggetto. Comunque dopo 6 giorni tutti i disturbi scomparivano affatto.<\/p>\n<p style=\"text-align: center\"><strong><span dir=\"ltr\">Referenze<\/span><\/strong><\/p>\n<p><span dir=\"ltr\">[1].<\/span><span dir=\"ltr\">The Lancet Diabets &amp; Endocrinology, 9 (21)<\/span><span dir=\"ltr\">[2].<\/span><span dir=\"ltr\">Anderson K.E. et al., Adv. Clin. Chem., 1976, 18, 247.<\/span><span dir=\"ltr\">[3].<\/span><span dir=\"ltr\">Blomhoff R. et al., S<\/span><span dir=\"ltr\">cience, 1990, 250 (4979), 399.<\/span><span dir=\"ltr\">[4].<\/span><span dir=\"ltr\">Clagett<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Dame M., DeLuca H.F., Annu. Rev. Nutr., 2002, 22, 347.<\/span><span dir=\"ltr\">[5].<\/span><span dir=\"ltr\">D\u2019Ambrosio D.N. et al., Nutrients., 2011, 3 (1), 63.<\/span><span dir=\"ltr\">[6].<\/span><span dir=\"ltr\">Feldman M.H., Schlezinger N.S., Arch. Neurol., 1970, 22 (1), 1.<\/span><span dir=\"ltr\">[7].<\/span><span dir=\"ltr\">Guillonneau M., Jacqz<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Aigrain E., Arch. P<\/span><span dir=\"ltr\">ediatr., 1997, 4 (9), 867.<\/span><span dir=\"ltr\">[8].<\/span><span dir=\"ltr\">Kowalski T.E. et al., Am. J. Med., 1994, 97 (6), 523.<\/span><span dir=\"ltr\">[9].<\/span><span dir=\"ltr\">H.C. Gorton e K Jarvis,<\/span><span dir=\"ltr\">The effectiveness of vitamin C in preventing and relieving the symptoms of <\/span><span dir=\"ltr\">virus<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">induced respiratory infections<\/span><span dir=\"ltr\">, in<\/span><span dir=\"ltr\">Journal of Manipulative and Physiological Therapeutics<\/span><span dir=\"ltr\">, 22(8), <\/span><span dir=\"ltr\">ottobre 1999, pp.<\/span><span dir=\"ltr\">530<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">3.<\/span><span dir=\"ltr\">[10].<\/span><span dir=\"ltr\">Rimbach G et al.: Regulation of cell signallin<\/span><span dir=\"ltr\">g by vitamin E. Proc Nutr Soc. 2002 Nov; 61(4):415<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">25. <\/span><span dir=\"ltr\">Review.<\/span><span dir=\"ltr\">[11].<\/span><span dir=\"ltr\">Azzi A et al.: The role of alpha<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol in preventing disease: from epidemiology to molecular events. <\/span><span dir=\"ltr\">Mol Aspects Med. 2003 Dec; 24(6):325<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">36. Review.<\/span><span dir=\"ltr\">[12].<\/span><span dir=\"ltr\">Zingg JM, Azzi A. Non<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">antioxidant acti<\/span><span dir=\"ltr\">vities of vitamin E. Curr Med Chem. 2004 May;11(9):1113<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">33. <\/span><span dir=\"ltr\">Review.<\/span><span dir=\"ltr\">[13].<\/span><span dir=\"ltr\">Traber MG. Utilization of vitamin E. Biofactors. 1999; 10(2<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">3):115<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">120.<\/span><span dir=\"ltr\">[14].<\/span><span dir=\"ltr\">Food and Nutrition Board, Institute of Medicine. Vitamin E. Dietary reference intakes for vitamin C, <\/span><span dir=\"ltr\">vitamin E, sele<\/span><span dir=\"ltr\">nium, and carotenoids. Washington D.C.: National Academy Press; 2000:186<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">283.<\/span><span dir=\"ltr\">[15].<\/span><span dir=\"ltr\">Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern <\/span><span dir=\"ltr\">Nutrition in Health and Disease. Philadelphia: Lippincott Williams &amp; Wilkiins; 2006:396<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">411.<\/span><span dir=\"ltr\">[16].<\/span><span dir=\"ltr\">Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is <\/span><span dir=\"ltr\">normalized by vitamin C supplementation. Free Radic Biol Med. 2006; 40(4):689<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">697.<\/span><span dir=\"ltr\">[17].<\/span><span dir=\"ltr\">Traber MG. Does vitamin E decrease heart attack risk? summary and implicat<\/span><span dir=\"ltr\">ions with respect to dietary <\/span><span dir=\"ltr\">recommendations. J Nutr. 2001; 131(2):395<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">397.<\/span><span dir=\"ltr\">[18].<\/span><span dir=\"ltr\">Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007; 27:347<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">362.<\/span><span dir=\"ltr\">[19].<\/span><span dir=\"ltr\">Christen S, Woodall AA, Shigenaga MK, Southwell<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">Keely PT, Duncan MW, Ames BN. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol traps mu<\/span><span dir=\"ltr\">tagenic electrophiles such as NO(X) and complements alpha<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol: <\/span><span dir=\"ltr\">physiological implications. Proc Natl Acad Sci U S A. 1997; 94(7):3217<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">3222.<\/span><span dir=\"ltr\">[20].<\/span><span dir=\"ltr\">Li D, Saldeen T, Mehta JL. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol decreases ox<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">LDL<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">mediated activation of nuclear factor<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">kappaB and<\/span><span dir=\"ltr\">apoptosis in human coronary artery endothelial cells. Biochem Biophys Res Commun. 1999; <\/span><span dir=\"ltr\">259(1):157<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">161.<\/span><span dir=\"ltr\">[21].<\/span><span dir=\"ltr\">Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, <\/span><span dir=\"ltr\">selenium, and subsequent prostate cancer. J Natl Can<\/span><span dir=\"ltr\">cer Inst. 2000; 92(24):2018<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">2023.<\/span><span dir=\"ltr\">[22].<\/span><span dir=\"ltr\">Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma<\/span><span dir=\"ltr\">&#8211;<\/span><span dir=\"ltr\">tocopherol, the major form of vitamin E in the <\/span><span dir=\"ltr\">US diet, deserves more attention. Am J Clin Nutr. 2001; 74(6):714<\/span><span dir=\"ltr\">\u2013<\/span><span dir=\"ltr\">722<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>IOSR Journal Of Pharmacy (e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219Volume 11, Issue 4Series. I(April2021), PP. 01-05www.iosrphr.org An ACE&#8211;based boisson (Elder tree syrup) enbodies a draconian remedy to prevent and combat seasonal flus&hellip;<\/p>","protected":false},"author":2,"featured_media":11114,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[202],"tags":[239,241,240,235,236,237],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/posts\/11109"}],"collection":[{"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/comments?post=11109"}],"version-history":[{"count":14,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/posts\/11109\/revisions"}],"predecessor-version":[{"id":11426,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/posts\/11109\/revisions\/11426"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/media\/11114"}],"wp:attachment":[{"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/media?parent=11109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/categories?post=11109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.texia.eu\/en\/wp-json\/wp\/v2\/tags?post=11109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}